Resources

Certifications

To view Pillar Biosciences’ quality management system certificate for ISO 13485:2016 issued November 24, 2017 please click here.

Publications

    "Application of ONCOREVEAL Lung & Colon Cancer Panel in CRC samples and effect of DNA damage in FFPE samples" AACR 2018 Conference Poster

    Access this poster presented by Jianfeng Xiao, Ph.D. at the recent American Association for Cancer Research in Chicago Illinois in April 2018.

    The poster presents results from over 200 FFPE samples used for evaluating the performance of the Pillar Biosciences’ ONCOReveal Lung & Colon Cancer Panel, with a subset of 27 samples selected for further analysis for DNA artifacts and effectiveness of repair.

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    A scientific poster presented by Dartmouth Hitchcock Medical Center at the Association for Molecular Pathology 2017

    Access this poster presented by Fran de Abreu, Ph.D. at the recent Association for Molecular Pathology conference in Salt Lake City, UT November 2017.

    The poster presents results from a total of 15 FFPE samples used for evaluating the performance of the Pillar Biosciences’ ONCO/Reveal Solid Tumor Panel, with the amount of genomic DNA input ranging from 17 – 72 ng and a total of 24 samples run on an Illumina MiSeq system using v3 chemistry.

    A median on-target rate of 99.57% and a median mapping rate of 99.11% are reported, with 100% concordance of previously reported results.

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    Amplification of overlapping DNA amplicons in a single-tube multiplex PCR for targeted next-generation sequencing of BRCA1 and BRCA2

    This July 2017 PLOS One paper outlines Pillar Biosciences’ method and further development of the SLIMamp™ technology, and also describes the results of full-gene BRCA1 and BRCA2 panel as applied to cell line DNA and remnant human DNA samples.

    Schenk D, Song G, Ke Y, Wang Z (2017) Amplification of overlapping DNA amplicons in a singletube multiplex PCR for targeted next-generation sequencing of BRCA1 and BRCA2. PLOS ONE 12(7): e0181062. https://doi.org/10.1371/journal.pone.0181062

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    "Evaluation of the Pillar NGS SLIMamp Lung and Colon Hot Spots Panel", a poster presented at the Association for Molecular Pathology 2016 in Charlotte, NC

    This poster was presented at the Association for Molecular Pathology 2016 conference held in Charlotte, NC and compared the performance of the Pillar Biosciences’ Lung and Colon Panel on an Illumina MiSeq™ to the Thermo Fisher Ampliseq™ Cancer Hotspot Panel v2 on the Ion Torrent PGM™.

    15 previously-characterized FFPE samples found a high degree of concordance (90.0%, 27/30 variants), and the Pillar Biosciences’ assay was shown to be highly reproducible at 5 ng and 50 ng input DNA. Allele frequency measurement reproducibility was also evaluated.

    J. Peterson, F. Blumental de Abreu, Z. Wang, W. Wells, G. Tsongalis, “Evaluation of the Pillar NGS SLIMamp Lung and Colon Hot Spots Panel”. Dartmouth-Hitchcock Medical Center, Lebanon, NH; Pillar Biosciences, Natick, MA

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