Lung Circulating Tumor DNA Panel

The ONCO/REVEAL High Sensitivity Lung Circulating Tumor DNA Panel is a targeted circulating free DNA (cfDNA)-based liquid biopsy solution for the sensitive detection of resistance or driver mutations from plasma samples. There is currently a large interest in using circulating tumor DNA detection in the bloodstream for treatment monitoring, for treatment sensitivity, as well as for its potential use for early detection. Unlike other assays on the market, the ONCO/REVEAL High Sensitivity Lung Circulating Tumor DNA Panel has a streamlined single-well processing approach, a very high on-target rate, and targets 17 known lung cancer oncogenes.

Unique Variants
Sample type circulating free DNA (cfDNA)
DNA input 20 ng cfDNA
Amplicon # 81
On target rate 93.2% ± 2.85%
Coverage uniformity %>0.20 × Mean: 99.8% ± 0.7%
%>0.15 × Mean: 100.0% ± 0.0%
Variant frequency 0.1%-0.2%
Lung Circulating Tumor DNA Panel Target Genes (17 in total)
AKT1 ERBB4 NRAS
ALK FGFR1 PIK3CA
BRAF FGFR3 PTEN
DDR2 KRAS STK11
EGFR MAP2K1 TP53
ERBB2 MET